From April 26th to 28th, Professor Gill attended the IARC (International Agency for Research on Cancer, part of the World Health Organisation) in Lyons France where the latest WHO classification of endocrine cancer was formulated by a panel of 22 experts in the field.
The WHO classification of cancers (also known as the WHO Blue Book series) is considered the gold standard for the diagnosis of human cancers and tumours. Based on the most up to date information and drawing upon the expertise of the 22 international experts from many different countries, each book represents a major consensus achievement in healthcare pathology on the global stage.
The new endocrine WHO blue book will be published in May 2017. If you're interested in endocrine pathology, you won't want to miss getting your very own copy!
We're very excited to have recently acquired Nanostring Technology's nCounter Analysis System equipped with the Prosigna module for breast cancer gene expression profiling. The Nanostring platform is particularly attractive to translational cancer researchers like us because of its demonstrated capability with FFPE material.
This month Mr Jonathon Osterhaus from Nanostring Technology US headquarters flew in to Sydney to show us how to use the Prosigna module to generate validated PAM50 molecular signatures on RNA extracted from FFPE breast cancer tissue. Breast cancer molecular signatures like the PAM50 provide information additional to routine pathology reports which can help fine-tune post-operative treatment to better suit individual patients.
The Nanostring platform is highly multiplexed. Using prefabricated reporter targets, so called code-sets, it is possible to simultaneously query up to 800 genes in a single FFPE sample without relying on gene amplification methodologies. We look forward to using this platform in conjunction with routine immunohistochemistry in the validation of exciting new potentially targetable cancer genes.
In his role as the lead pathologist for the Australian Pancreatic Genome Inititative (APGI), Anthony Gill attended the 9th Scientific Workshop of the International Cancer Genome Consortium (ICGC) at the Chinese Academy of Medical Sciences in Beijing, China.
The ICGC is an international consortium of cancer researchers whose goal is to perform genomic, epigenomic and transcriptomic sequencing of major cancer types to better understand how they develop and behave. This in turn is envisioned to result in more effective ways to treat cancer in the near future. Researchers include scientists and healthcare professionals dedicated to fight cancer.
Australia's contribution to ICGC is world class research into pancreatic cancer, an insidious and devastating disease with a dismal prognosis despite advances in modern surgery. To read more about the Australian Pancreatic Cancer Genomic Initiative please visit this link.
ICGC researchers and clinicians from all over the globe met in Beijing to discuss results, compare findings and map out future collaborations.
16 January 2014
Over a hundred participants, including practising surgical pathologists, pathology trainees and scientists, attended this evening's Update on Urologic Cancer at the Kolling Institute. After light refreshments and a quick opportunity for some social networking(!), we adjourned to the auditorium to hear lectures on the latest International Society of Urological Pathology (ISUP) updates on kidney and prostate cancer.
We also heard about practical tips for renal cancer reporting and the fascinating world of hereditary renal cancers, including the recently described succinate dehydrogenase mutation associated renal carcinoma, a new provisional renal cancer type. An Australian case report of this rare cancer has recently been published in the Journal of Clinical Oncology. The evening concluded with light refreshments and an opportunity for participants to address questions to the presenters.
A big thank you to everyone who came and made the evening a success! Photo. Top left - Prof Trpkov presenting on ISUP renal cancer updates. Right - Anthony talking about his work on SDH mutation associated renal carcinoma.
15 November 2013
The Kolling Foundation is the fund-raising arm of the Kolling Institute of Medical Research in Sydney, Australia, where we and many other cancer research groups like us, are based. To find out more about research activities at the Kolling Institute please visit this link.
In this age of healthcare research dollar rationalisation, your donations, no matter how small, are more vital than ever before to help us keep making discoveries.
2 August 2013
Tonight we exchanged our lab coats for formal attire and a gala evening of gourmet food and music at the 2013 New South Wales Premier's Awards For Outstanding Cancer Research.
This event, hosted annually by the NSW Cancer Institute to honour excellence in cancer research, was held at the NSW State Art Gallery, hosted by the scintillating wit of renowed ABC radio journalist and TV presenter Mr Adam Spencer and the mesmerising Ms Katie Noonan who serenaded on solo acoustic keyboard.
We proudly congratulate our group leader A/Prof Anthony Gill for being honoured by the NSW Cancer Institute with the prestigious Excellence in Translational Cancer Research Award with his long-time colleague and collaborator A/Prof Roderick Clifton-Bligh. The award is in recognition of their joint research efforts in developing and implementing a screening program for patients with hereditary cancer syndromes associated with phaeochromocytoma / paraganglioma, gastrointestinal stromal tumour (GIST) and renal carcinoma.
Dr Diana Benn, a senior member of Roderick's Cancer Genetics research group at the Kolling Institute, was with us in place of Roderick to receive the joint award, who regrettably was unable to attend. We were pleasantly surprised as Anthony had kept the secret of his nomination well hidden. Luckily we were able to capture the moment with an iPad Mini on hand!
We heartily congratulate Anthony, Roderick, and all award winners, for their tireless work in helping improve cancer outcomes for all, and for continuing to inspire a whole new generation of scientists and clinicians in translational cancer research.
22 July 2013
Congratulations to our current University of Sydney medical student affiliates Aditi Raut, Lucy Mylchreest, Jessica Mills and Isobel Yeap for winning the RCPA Scholarship for Medical Schools award. The prizes were presented by Prof Jonathan Morris, head of the Northern Clinical School and the Kolling Institute (left panel).
The RCPA Scholarship for Medical Schools award is valued at AUD$2000 and intended to foster early interest in cancer pathology research among medical students. We are proud to announce that our medical student affiliates have won the prize in three of the last four years!
Moving forwards, Isobel, Lucy, Aditi and Jessica (right panel, from left to right) are establishing a breast cancer research interest group for medical students and will use the award to support research in potential targeted treatments for breast cancer. We wish them all the very best with their medical and research careers.
31 May - 2 Jun 2013
It's the time of year again for the Annual Scientific Meeting of the Australasian Division of the International Academy of Pathology Limited (IAP) in Sydney, Australia.
Christopher Toon presented the group's research work on BRAFV600E immunohistochemistry in colorectal cancer at the gastroenterology companion meeting, chaired by A/Prof Priyanthi Kumarasinghe from PathWest, WA.
The talk highlighted the utility of performing BRAFV600E with mismatch repair enzyme deficiency immunohistochemistry to improve screening for Lynch Syndrome and identify microsatellite stable BRAFV600 mutant colorectal cancers which new research is showing to have a worse prognosis.
7 -8 February 2013
Prof Anthony Gill has just returned from an exhilarating trip to the beautiful southern Indian state of Tamil Nadu. He was invited to present a series of guest lectures at the Update in Thyroid Pathology Conference. Hosted by the world-renowned Christian Medical College in Vellore, there were well over three hundred pathologists in attendance from across the Indian subcontinent.
Official conference photograph. On Anthony's right is Prof Ashraf Khan from the University of Massachussetts, USA. Seated on Anthony's left is Conference Convenor Prof Sheila Nair from the Christian Medical College, Vellore, India.
Anthony delivered lectures on molecular pathology of thyroid neoplasia, immunohistochemistry in thyroid neoplasia as well as mitochondrial driven neoplasia. He also hosted a slide seminar of difficult diagnoses in thyroid neoplasia and attended the pathology department at the Christian Medical College where he presented his current research findings and commented on difficult cases.
The bustling city of Vellore - home of the 2500-bed Christian Medical Centre
The official opening of the conference with a traditional puja blessing ceremony.
12 December 2012
Congratulations to our newest group member Dr Michelle Houang for being awarded the NSW Cancer Council's NTCRU 2013 clinical fellowship. Michelle is a post Part 1 anatomical pathology trainee with the Royal College of Pathologists of Australasia, currently based at the Royal NorthShore Hospital.
Her 2013 research project will investigate the role of embryonic transcription factors in the evolutionary biology of malignant melanoma, with special emphasis on the development of diagnostics which may have clinical relevance in the management of patients with melanoma. One of the main difficulties confronting clinicians is how to distinguish malignant melanoma from benign melanocytic lesions, something this project also hopes to address.
Prof Anthony Gill recently lectured at the Malaysian International Anatomical Pathology Update held in Kuala Lumpur, Malaysia. He had been invited to present our group's research work on telepathology.
Photo (left). As part of the official party Anthony looks on as Amanda Herbert from the UK, Sheila Nair from Malaysia and the World Pathology Foundation (WPF) President Robby Bacchus cut a cake to celebrate the 40th anniversary of the WPF.
Photo (right). The faculty of the Malaysian IAP meeting 2012. Standing from the left: Dr Amanda Herbert, Dr Eduardo Calonje, Prof C Simon Herrington, Assoc Prof Anthony Gill, Prof Kiril Trpkov. Seated from the left: Dr Robby Bacchus (President WPF), Yg Bhg Dato’ Dr Hj Azman bin Abu Bakar (Selangor State Director of Health), Dato’ Dr Norain Karim (Chairman of Organizing committee of IAPU 2012).
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